PREVENELLE® – a cost effective equivalent to Norlevo®

  • PREVENELLE® Contains 1.5mg levonorgestrel¹
  • Its indicated for emergency contraception within 72 hours of unprotected sexual intercourse or failure of a contraceptive method¹
  • Prevents ovulation & fertilisation if intercourse has taken place in the preovulatory phase¹
  • Prevenelle® has a pregnancy rate of 1.01% according to the meta-analysis of 3 independent WHO studies² and 2.15% according to the meta-analysis of Glasier et al (2010) and Crenin et al (2006)³
  • Prevenelle® is the only GMS reimbursed levonorgestrel emergency contraceptive – GMS Number: 45961
  • Prescribing status  – can be dispensed with or without a prescription¹
  • Well known, effective, trusted medicine with an acceptable safety profile¹
  • 1.5 mg levonorgestrel has been manufactured since 1979 by the No. 1 emergency contraception manufacturer Gedeon Richter Plc 5
  • Helped more than 400 million women avoid pregnancy for over 35 years 5

PREVENELLE®  is suitable for: 1,4

  •  Women who have had unprotected sex in the last 72 hours
  • Women who are currently taking hormonal oral contraception (use of barrier method e.g. condom, until the next menstrual period starts is advised following the intake of Prevenelle®)
  • GMS Medical Card Patients
  • Breast feeding women*

*Women need to stop nursing for 8 hours following administration of Prevenelle®²

According to latest guidelines published by the Faculty of Sexual and Reproductive Healthcare, emergency contraceptive providers should be aware that: 8

  • The effectiveness of ulipristal acetate (ellaOne) could be reduced if a woman takes progestogen in the 5 days after taking ellaOne
  • The effectiveness of ellaOne could theoretically be reduced if a woman has taken progestogen in the 7 days prior to taking ellaOne.
  • If the patient estimates that unprotected sexual intercourse is unlikely to have occurred during her fertile period, she may consider the option of using levonorgestrel containing emergency contraceptive containing Prevenelle (or Norlevo) with immediate start of hormonal contraception rather than ellaOne with delayed start of hormonal contraception.

PREVENELLE® has exactly the same active ingredients as Norlevo® 1,6

As listed in MIMs the NET wholesale price of Prevenelle® is €6.31 while Norlevo® is €11.82⁷

References:

  1. Prevenelle® SmPC – available at www.medicines.ie
  2. 1.01% pregnancy rate, WHO meta-analysis, EMA Assessment report 24/07/2014
  3. Glasier AF, Cameron ST, Fine PM, et al. Ulipristal acetate versus levonorgestrel for emergency contraception: a randomised non-inferiority trial and meta-analysis. Lancet 2010; 375: 555-562.
  4. HSE: Primary Care Reimbursement Service – List of Reimbursable Items. August 2017
  5. 2013 IMS/PharmExpert in volume and value
  6. Norlevo® SmPC – available at www.medicines.ie
  7. MIMS Ireland (August 2017) ‘Contraception’ MPI Media Ltd, Dublin
  8. Faculty Sexual Reproductive Healthcare Emergency Contraception Guidelines updated May 2017

IE-OCS-284 Date of preparation: July 2019


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